Early peek at data on Gilead coronavirus drug suggests patients are responding to treatment By Adam Feuerstein

https://www.statnews.com/2020/04/16/early-peek-at-data-on-gilead-coronavirus-dru

A Chicago hospital treating severe Covid-19 patients with Gilead Sciences’ antiviral medicine remdesivir in a closely watched clinical trial is seeing rapid recoveries in fever and respiratory symptoms, with nearly all patients discharged in less than a week, STAT has learned.

Remdesivir was one of the first medicines identified as having the potential to impact SARS-CoV-2, the novel coronavirus that causes Covid-19, in lab tests. The entire world has been waiting for results from Gilead’s clinical trials, and positive results would likely lead to fast approvals by the Food and Drug Administration and other regulatory agencies. If safe and effective, it could become the first approved treatment against the disease.

The University of Chicago Medicine recruited 125 people with Covid-19 into Gilead’s two Phase 3 clinical trials. Of those people, 113 had severe disease. All the patients have been treated with daily infusions of remdesivir. 

“The best news is that most of our patients have already been discharged, which is great. We’ve only had two patients perish,” said Kathleen Mullane, the University of Chicago infectious disease specialist overseeing the remdesivir studies for the hospital.

Her comments were made this week during a video discussion about the trial results with other University of Chicago faculty members. The discussion was recorded and STAT obtained a copy of the video.

The outcomes offer only a snapshot of remdesivir’s effectiveness. The same trials are being run concurrently at other institutions, and it’s impossible to determine the full study results with any certainty. Still, no other clinical data from the Gilead studies have been released to date, and excitement is high. Last month, President Trump touted the potential for remdesivir — as he has for many still-unproven treatments — and said it “seems to have a very good result.”

Well, That Unraveled Quickly Jeffrey A. Tucker

www.aier.org/article/well-that-unraveled-fast/?fbclid=IwAR3ebwR3aOQhqmdmQKObvQ-AnnTukHghQ-bo-AI1dX2l3vbvraxkXTtJfXQ

Thinking back to February 28, 2020, and the New England Journal of Medicine. It published an article called “Covid-19 — Navigating the Uncharted” signed by Anthony S. Fauci (THE Fauci), Clifford Lane, and Robert R. Redfield.  

It reported an existing COVID-19 case fatality rate of 2% but further pointed out that infections show “a wide spectrum of disease severity.” “If one assumes that the number of asymptomatic or minimally symptomatic cases is several times as high as the number of reported cases, the case fatality rate may be considerably less than 1%” or perhaps as high as the flu seasons of 1957 and 1968, but is nowhere near “a disease similar to SARS or MERS, which have had case fatality rates of 9 to 10% and 36%, respectively.” To be sure, they said, mitigating the disease could require “isolating ill persons (including voluntary isolation at home), school closures, and telecommuting where possible.”

Now, what precisely happened between February 28 and two weeks later? This will be studied for many years to find out precisely how governors and mayors, through a series of unscientific, panicked, unjustified, and morally egregious actions, crushed under foot the world’s strongest economy while the media cheered. We’ll be discussing the whys and whats for a generation. 

The point is that it is all unraveling as fast as it came. Donald Trump’s press conference on April 16, 2020, was clearly a turning point. In my ideal world, we would have officials up there telling the truth that the course we took as a nation was catastrophic in countless ways (except for all the panicked deregulation undertaken just so that the food and medicine could continue). But I’m realistic: we can hardly expect politicians to bow down and beg forgiveness. 

Could anti-lockdown protests be new Tea Party movement? W. James Antle III

www.washingtonexaminer.com/news/could-anti-lockdown-protests-be-new-tea-party-movement

Growing discontent with stringent state-level restrictions imposed to mitigate the coronavirus is pouring out into the streets near state capitols in ways reminiscent of the last decade’s conservative activism.

“They have a very Tea Party feel,” said Tea Party Express co-founder Sal Russo of the demonstrations.

“The current protests are because of government overreaching and infringing on our rights,” said Tea Party Patriots founder Jenny Beth Martin. “The protests are an extension of what the Tea Party movement has stood for the last 11 years — constitutionally limited government, personal and economic freedom. In the time of crisis and to remain on solid ground with those whom they represent, elected officials should lean on the Constitution, not abandon it.”

President Trump lent his encouragement Friday, sending three separate tweets calling on protestors to “LIBERATE” a trio of 2020 battleground states, Michigan, Minnesota, and Virginia, each with Democratic governors whose approaches to slowing the pandemic are seen in some quarters as draconian.

One of these chief executives, Michigan Gov. Gretchen Whitmer, has been locked in a feud with Trump and is a co-chairman of presumptive Democratic nominee Joe Biden’s campaign. She is frequently mentioned as a possible Biden running mate. Trump also used the occasion to blast gun control policies signed into law by Virginia Gov. Ralph Northam, urging the state’s residents to “save your great 2nd Amendment. It is under siege!”

The protests may be an early sign of burgeoning conservative sentiment in favor of reopening businesses that have been shuttered to manage the spread of the coronavirus. While polling still shows broad public support for social distancing, some partisan fissures are beginning to appear over the massive job losses. In a recent Morning Consult poll, 51% of Republicans said the public health impact was more important than the quarantines’ economic consequences to 43% who said otherwise. The split among all voters was 64-29.

What is the meaning of America First? Diane Bederman

https://dianebederman.com/what-is-the-meaning-of-america-first/

“From this day forward,” Trump said at one point, “it’s going to be only America first. America first.”

We hear a lot today about the term America First; always attached by politicians, pundits and professors to Donald Trump, and in a derogatory manner.  America First is a racist term they say. It was. There is a show on TV now called; The Plot Against America,  based on a novel by Philip Roth,  that takes place around the time of the Second World War.  At that time there was a group of people calling themselves America First which had its roots in the America First Committee (AFC), founded in 1940. These people opposed any U.S. involvement in World War II, and were harshly critical of the Roosevelt administration, which it accused of pressing the U.S. toward war. At its peak, it had 800,000 members across the country, included socialists, conservatives, and some of the most prominent Americans from some of the most prominent families. There was future President Ford; Sargent Shriver, who’d go on to lead the Peace Corps; and Potter Stewart, the future U.S. Supreme Court justice. It was funded by the families who owned Sears-Roebuck and the Chicago Tribune and of course had its share of antisemites.

These people walking around calling for America First tended to be white Christians who wanted America to remain white and Christian. Echoes of their German compatriots who called for Germany to be an Aryan nation, nice, white, blond people. No one else. I don’t know if it is hypocritical or ironic that the man behind the plan was dark haired and looked nothing like his idealized Aryan German.

America First.  That was white nationalism, white racism and antisemitism.

That was then.

Swans of a Different Color By David Solway

https://www.americanthinker.com/articles/2020/04/swans_of_a_different_color_.html

The next catastrophe might not be a virus

The advent of COVID-19 and the subsequent nation-wide lockdown amounts to a wake-up call of historical proportions. It has alerted us to the possibility of “black swans” swimming into our lives, or in the words of Nassim Nicholas Taleb in his bestselling The Black Swan, our susceptibility to “the role of the exceptional event leading to the degradation of predictability.”

A “black swan” is characterized by three attributes: “it is a rarity,” “it causes an extreme impact,” and we come to understand it only “after the fact.” The terrorist attack of September 11, 2001 was such a “black swan” — a malign event we did not expect and plan for. At the same time, most beneficial discoveries and technologies did not come from design, planning or predictable outcomes but were rare events with positive implications; for example, Sir Alexander Fleming’s accidental discovery of penicillin. But what most concerns us is the negative “black swan,” with its destructive radius owing much of its malignity to the “built-in defect of conventional wisdom.”

Of course, the trope of the “black swan” is not Taleb’s invention but enjoys a long pedigree, going back to the Latin poet Juvenal’s sixth Satire against marriage, where the perfect wife is considered a disaster since she would be impossible to live with. In other words, something “good” = something “bad.”

Rally ’Round the Flag, But Not Around Cuomo Why New York’s governor seems to be benefitting from the flag effect more than President Trump isn’t too difficult to understand. By Elliot Fuchs

https://amgreatness.com/2020/04/18/rally-round-the-flag-but-not-around-cuomo/

An apolitical friend reached out to me the other day with an honest question: Is Andrew Cuomo the best governor in the United States?

The answer to that question is a hard “no,” but my friend is not the only one thinking that way, especially among New Yorkers.

A new poll, under the headline “Cuomo Threatens Trump” shows Cuomo’s numbers skyrocketing during his handling of the coronavirus crisis and has him challenging Trump seriously in a head-to-head matchup. Polls show the president’s approval ratings moving upward during the crisis, too. Both of these politicians seem to be leveraging their nationally televised Corona briefings toward general approval of their handling of the situation.

The truth is both of these politicians seem to be benefiting from the “rally ’round the flag effect.” Seen most spectacularly during 9/11, the “rally ’round the flag effect” is a term coined by political scientists to describe how Americans tend to favor their leaders during times of national distress. During “the most spectacular of international crises,” government officials can expect “a public rally.” This is how we can understand President George Bush’s astounding approval rating of 90 percent during the intial outbreak of “the war on terrorism.” Or FDR’s 84 percent approval rating during the Great Depression, even though some economists have questioned if his actions actually prolonged our economic burdens, and didn’t help alleviate them.

A Deadly if Dutiful Deference The American public has been dutiful to the point of self-harm in heeding the injunctions of the people who manage their lives and livelihoods. By Roger Kimball

https://amgreatness.com/2020/04/18/a-deadly-if-dutiful-deference/

On March 14, when the current coronavirus hysteria was beginning to get going in earnest, I said “one of the silver linings” of this panic would be that “the people who will be blamed when it is over—which it will be, and soon—are the people who stoked the insanity.”

That was a little over a month ago and guess what? “Soon” is “now.”

I am not thinking primarily about the burgeoning protests against the draconian and largely pointless “lockdowns” and interdictions ordered by power-hungry governors and other high-handed politicians. Those have been gratifying, and I suspect that the protests against really egregious actors, like Gretchen “Cruella de Vil” Whitmer, the wretched governor of Michigan, at least for now, will only gather momentum in the coming weeks.

But I am hoping that the deeper and longer-lasting response will be a quiet revolution in sentiment against the people who abetted this wealth-destroying panic: against the media, first of all, but also the obscure bureaucratic elite that stoked the fear and helped spread the hysteria.

Every day, it seems, brings new reasons to distrust the models and projections that turned the American public into a fearful, quivering jelly. A month ago we were told that unless we turned our world into a giant condom and took care not to touch anyone or anything, millions would die. In recent weeks, those numbers have been revised downwards again and again, even as the strategies for counting cases and fatalities due to the insidious new virus have spiraled upwards. There is a great eagerness in municipalities thirsty for government funding to overstate the number of people affected by the virus.

In New York, the smoldering omphalos of the disease in America, with just over 40 percent of the cases nationwide, a third of fatalities were not even tested. Rather, they are said to have succumbed to “COVID-19 or an equivalent.” An equivalent, Kemo Sabe, like those generic drugs made in China that are supposedly the equivalent of the brand name varieties.

Things are moving quickly now. After losing some 10,000 points in a few weeks, the market has regained more than 5,000 points just as abruptly. Who knows whether that rally will continue. It’s pretty clear, though, that many of the 20 million jobs that evaporated and tens of thousands of businesses large and small that have been crushed will not be coming back. How do we deal with that?

Made in the USA: Winning Out over Enemies of Democracy by Lawrence Kadish

https://www.gatestoneinstitute.org/15902/made-in-the-usa

Today, America must meet the challenge of the Coronavirus and Civilization-Abusers. We did it in years past, with patriotic Americans and a determined mobilized military against the Axis Nations — Japan, Germany, and for a time Italy — as well as against polio with the Salk and Sabin vaccines.

Whether it is in developing 5G or other technologies, America needs to mobilize and be the world’s leading export nation, the same way we became energy independent and a leading energy-exporting nation.

We have to grow our economy and not rely on enemies of democracies to import our essential goods, either medical or technological.

Kids are eager to soak up from television what people have done to make America great. Uplifting American “can-do” educational programming and documentaries could cheer them up and show them the way.

Eighty years ago, it was Hitler and Pearl Harbor, and more recently 9/11.

Today, America must meet the challenge of the Coronavirus and Civilization-Abusers. We did it in years past, with patriotic Americans and a determined mobilized military against the Axis Nations — Japan, Germany, and for a time Italy — as well as against polio with the Salk and Sabin vaccines.

APRIL 19, 1943- PASSOVER: THE WARSAW GHETTO UPRISING

Shortly after the German invasion of Poland in September 1939, more than 400,000 Jews in Warsaw, the capital city, were confined to an area of the city that was little more than 1 square mile.

On April 19, 1943, on Passover, Himmler sent in SS forces and their collaborators with tanks and heavy artillery to liquidate the Warsaw ghetto.

Several hundred resistance fighters, armed with a small cache of weapons, managed to fight the Germans, who far outnumbered them in terms of manpower and weapons, for nearly a month.

However, during that time, the Germans systematically razed the ghetto buildings, block by block, destroying the bunkers were many residents had been hiding. In the process, the Germans killed or captured thousands of Jews.

By May 16, the ghetto was firmly under Nazi control, and on that day, in a symbolic act, the Germans blew up Warsaw’s Great Synagogue.

The European Union is Dead but Does Not Yet Know It by Giulio Meotti

https://www.gatestoneinstitute.org/15894/european-union-dead

The truth is that there is no “Union”.

The coronavirus now has put the European Union and its comfort zone face-to-face with all its weaknesses, decadence and cowardice.

Another merciless battle Italy fought with the EU was for protective face-masks. France adopted a policy of requisitioning them; Germany banned their export. Those unilateral decisions undermined a much-touted EU principle: the free movement of goods in the single market.

As L’Express exposed, France seized four million masks belonging to a Swedish company and that had been intended, in part, for Italy and Spain.

When Italy and Greece were overwhelmed by migrants from the Middle East and Africa, the EU countries refused to take their “share” of migrants. Lacking a policy to stop the flow of mass immigration, Europe decided to leave the southern countries to their fate.

The new coronavirus appears to be tearing apart the fragile framework of the European Union.

“Europe” said the former Commission chief and a EU godfather, Jacques Delors, “is in “mortal danger”.

If citizens feel themselves abandoned at the heart of the pandemic, said Former French Prime Minister Manuel Valls, the EU could “collapse”.