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Israeli Researchers Discover Why Cancer Recurs – And Fight Back By Einat Paz-Frankel

Even with today’s safer and more targeted anti-cancer drugs, scientists have been unable to satisfactorily explain the phenomenon of why treated cancers so often recur. The common theory is that the cancer cell develops internal resistance to treatment, and overrides the toxic effects of the drug.

Now, a team of Israeli scientists provide the key for reducing recurrence, allowing anti-cancer drugs to do work as intended.

Led by Prof. Yuval Shaked of the Technion-Israel Institute, the study shows that tumor relapse occurs when the body, in effect, mobilizes itself in favor of the tumor, causing recurrence of the disease, increasing its aggressiveness and creating metastases (tumor spread). Even selective, highly focused treatments that almost exclusively harm cancer cells lead to a similar response.

“The administration of an anti-cancer drug is very aggressive intervention in the body,” Shaked said in a statement. “Therefore, the body responds to chemotherapy the way it responds to trauma. This creates the effect of a double-edged sword: although chemotherapy kills cancer cells, it also causes the secretion of substances that confer resistance to the tumor.”

The study, which was recently published in the scientific publication The Journal of Pathology, mice with multiple myeloma – a malignant disease of the plasma cells produced in bone marrow and spread throughout the body – were treated with the selective anti-cancer drug Velcade (bortezomib). Velcade is based on the discovery of ubiquitin, for which professors Avram Hershko and Aaron Ciechanover of the Technion won the Nobel Prize (along with the late American biologist Irwin Rose) in 2004.

Shaked found that treatment with Velcade led to a physiological reaction that actually reinforced the intensity of the myeloma in the mice. According to Shaked, the drug caused inflammatory cells in the bone marrow to enhance the aggressiveness of the disease and provide the cancer cells with resistance to treatment. Still, “treatment with Velcade is essential and necessary,” says Shaked, “but its disadvantage is that along with the benefit there is damage.”

Next steps: Inhibiting the mechanism that enhances the tumor

Understanding the mechanisms that enhance the tumor and accelerate the spread of metastases “will enable us to develop methods to inhibit them,” he stresses. In fact, when the researchers inhibited the secreted factor related to the activity of inflammatory cells, they observed a decrease in the proliferation of cancer cells. Now, they are working on various ways to inhibit the body’s response to anti-cancer treatments.

Turkey’s Wars By Stephen Bryen and Shoshana Bryen

Turkish air and ground forces are attacking northern Syria. The target is not ISIS – the presumed threat to Turkish interests – but rather Kurdish forces that have borne the brunt of anti-ISIS ground fighting and are key to the battle for Mosul in Iraq.

Since the July aborted coup in Ankara, the government of Recep Tayyip Erdoğan has been making internal war against what it calls the “Gülenist threat,” followers of Turkish cleric Fetullah Gülen, who Erdoğan believes engineered the coup. Tens of thousands of Turks have been arrested, dismissed from their jobs, and otherwise harassed. Turkey has also been conducting an external war – either overtly or by proxy – to control sensitive areas of Iraq and Syria and short-circuit any possibility of Kurdish independence or large-scale autonomy emerging from the wreckage of wars in both those countries.

After shelling Kurdish positions just north of Aleppo, the Turkish Air Force bombed headquarters, ammunition dumps, and shelters. Turkish sources claimed 200 dead; Kurdish sources said 10 people were killed. They were PKK, said the Turks – members of the Peoples Workers Party, which has carried out operations inside Turkey for decades. The People’s Protection Units (YPG), however, said in a statement that the airstrikes targeted fighters from the YPG-affiliated Jaish al-Thuwar (Revolutionary Front), which was advancing against ISIS in the city of Ifrin.

Turkey makes little distinction among Kurdish groups. The U.S. takes a different tack, agreeing that the PKK is a terrorist organization but arming and training the YPG and finding it the most effective force on the ground fighting ISIS. A U.S. official says the particular Kurds targeted this time were not among those we have trained, so there were no Americans in the area of Turkish fire. This time. But the possibility of direct U.S.-Turkish confrontation is rising daily.

There has been little mention of Turkey’s wars in the American press, aided by the fact that militias, rebel armies, terrorist groups, and sub-state actors sound like alphabet soup: FSA, PKK, PYD, YPG, JAN, ISIS, AQI, and more fight in Syria and Iraq. Even when they have names, Americans are likely to find themselves confused. How does Jaish al-Thuwar relate to the Khalid ibn al-Walid Brigade, or the Free Syrian Army or the Authenticity and Development Group, the Sun Battalion, the Al-Qousi Brigade, or the Truthful Promise Brigade?

Confusion is serving Turkey well.

The Mosul Offensive’s Many Unknowns By:Srdja Trifkovic |

The much-heralded offensive against ISIS in Mosul by the Iraqi army, Kurdish Peshmerga and Shiite militias may succeed in capturing Iraq’s second largest city. It is unlikely to result in the destruction of the Islamic State’s fighting capacity, however. It is even less likely to lead to the establishment of stable and permanent government control over Iraq’s Sunni Triangle, which has Mosul at its northern tip.

The importance of Mosul is clear. It is a major population center of over two million (before the war) and the pivot that intersects the east-west line of communication from the Syrian border to the north-south axis that leads to Baghdad, 250 miles to the south. The first question, which has not been adequately considered in mainstream media reports, concerns the battle readiness of government forces. In June 2014 the Iraqi army collapsed and fled without a fight when ISIS attacked Mosul, although it was vastly superior to the attackers in numbers and equipment. The high command in Baghdad was unable to maintain any semblance of command and control, even though the U.S. had spent some 20 billion dollars on arming, training and equipping it in preceding years. Its mostly Shiite soldiers were uninterested in fighting for Sunni-majority areas which they did not regard as their own. It was unable to develop any sense of loyalty or common purpose among its non-Shia recruits, who deserted en masse.

It is unclear what if anything has changed over the past two years and four months to shift the balance. The personnel, equipment, training and doctrine are still largely the same. Early signs were not encouraging. On the first day of the current offensive it took the Iraqi army six hours of fierce combat to push back a platoon-sized IS unit from Ibrahim Khalil, a village 20 miles south of Mosul. The jihadists came back and retook the village during the night: “No reinforcements showed up so when they attacked we had to retreat from the five villages we captured on Tuesday. We ended up right back where we started,” said Lieutenant-Colonel Mohammed Hadi. “We took back three today but we can’t advance further towards Mosul until the others arrive.” This episode bodes ill for the future of a complex operation which requires precise planning and coordination. Subsequent army claims of battlefield successes, such as the taking of the city of Bartella on October 21, may reflect the unwillingness of ISIS to give battle in open plains south of the city where its fighters would be at an obvious disadvantage.

Red Alert! Protestant Couple “Security Threat” to Turkey! by Burak Bekdil

The Islamophobia that Erdogan never ceases to claim exists in the Western world may or may not be a real social malady, but non-Muslimphobia in Turkey is increasingly a contagious malady.

“Traitors! We’ll bomb your church!” — The words of Mehmet Ali Eren, suspected al-Qaeda member, as he attacked Protestant Pastor Andrew Craig Brunson in Izmir, Turkey.

Erdogan should explain why he persistently demands more and more tolerance for Muslims living in non-Muslim lands, including the building of mosques in every capital, while his government can deport Pastor Brunson and his wife on the spurious grounds that they pose a security threat to his country. The police explained that they were being expelled on grounds of posing a security threat because they had carried out “missionary activity and received money from sources abroad.”

Over the past several years Turkish President Recep Tayyip Erdogan has pressured Greece to construct a mosque in Athens. He has criticized the country which boasts the only European capital without a mosque. He does not hide his passion for mosques worldwide.

In 2015 Erdogan proposed the construction of a mosque in secular, Communist-ruled Cuba. Also in 2015, he went to Moscow for the inauguration of the biggest mosque in the Russian capital.

Earlier this year Erdogan pleasantly announced his presence at the opening of the biggest mosque in Amsterdam. The mosque is called “Hagia Sophia,” named after a Greek Orthodox Christian basilica built in 537 AD in Constantinople, reflecting the typical Muslim extremist obsession with “conquest.” Recently Erdogan has also been eyeing Iraq.

As recently as April, Erdogan attended the opening ceremony of a culture center and mosque in Maryland, United States. The complex, the only one in the United States to feature two minarets, was constructed in the style of 16th century Ottoman architecture, with a central dome, half domes and cupolas, echoing Istanbul’s Suleymaniye Mosque. At the ceremony, Erdogan said: “Unfortunately, we are going through a rough time all around the world. Intolerance towards Muslims is on the rise not only here in the United States but also around the globe.” Intolerance toward Muslims?

Russian Warships Sail Through English Channel Display of naval might comes as EU leaders renew calls on Russia to stop attacks on Aleppo By Nicholas Winning

LONDON—A fleet of Russian warships, including the country’s sole aircraft carrier, sailed through the English Channel on Friday in a very public display of naval might after European leaders again called on Moscow to stop its attacks on Aleppo, Syria.

The U.K. Ministry of Defense said two Royal navy ships, the frigate HMS Richmond and destroyer HMS Duncan, were escorting the Russian ships as they sailed in international waters down the U.K.’s eastern seaboard. The Russian ships, including the aircraft carrier Admiral Kuznetsov and nuclear powered Kirov Class battlecruiser Pyotr Velikiy, are thought to be heading for the Mediterranean Sea.

European Union leaders at a two-day summit in Brussels held off on threatening Russia with sanctions for supporting the Assad regime’s siege of Aleppo following objections from Italy. Instead, EU leaders said all options remained on the table if the bombing continues.

Jens Stoltenberg, the North Atlantic Treaty Organization secretary-general, said Thursday he was concerned about the deployment of a Russian aircraft carrier to the Mediterranean possibly taking part in strikes on Aleppo. Mr. Stoltenberg said the alliance’s navies would monitor the Russian ships as they travel to the Mediterranean.

U.K. Defense Secretary Michael Fallon said Thursday at a defense conference in London that the Russian deployment was, “clearly designed to test the alliance,” adding that the ships would be “marked every step of the way” by British and NATO ships.

U.S. Troops in Iraq Don Gas Masks as Islamic State Sets Fire to Industrial Waste Noxious smoke from burning sulfur at an industrial area affects U.S. base By Ben Kesling and Gordon Lubold

Islamic State militants set fire to sulfur stocks outside an industrial plant south of Mosul earlier this week, the U.S. military confirmed Saturday, creating a plume of noxious smoke that has drifted over nearby towns and a U.S. military base, forcing some troops to put on gas masks as a precaution.

Militants set the residue alight at the Mishraq industrial plant as a tactical measure to slow Iraqi military advances in the offensive to recapture Mosul, adding to oil-well fires started weeks ago and still burning in Qayara. The combination is now affecting the nearby U.S. base as shifting winds blow the smoke toward the troops.

“Daesh ignited toxic sulfur residue stored at al-Mishraq (south of Mosul) in an attempt to disrupt the ISF advance,” Col. John Dorrian, spokesman for the U.S.-led coalition in Iraq, said in a statement, using another name for Islamic State. He added that the military is now assessing the risk to U.S. troops because of the multiple fires.

It is unclear whether officers or senior troops ordered soldiers to put on the masks or if the troops chose to do so themselves as a precaution.

Europe’s Terror Challenges: The Returnee Threat : Abigail Esman

Another week, another barrage of headlines illustrating the depth of Europe’s terror threat. The following examples came during a 24 hour window earlier this month: “Schiphol Airport Was Possibly A Target Of Terror Cell That Attacked Paris;” “Police In Brussels Stabbed In Possible Terror Attack;” and “MI5 Missed Chance To Foil Paris And Brussels Attacks.”

It is news to no one that Islamic terrorism is everywhere now, and principally in Northern and Central Europe. But the three news stories, and the Schiphol and MI5 revelations in particular, demonstrate the enormity of the challenges now facing European counterterrorism officials.

Intelligence and law enforcement continue to fumble in handling the threat, often through no real fault of their own. The perpetrators are slippery and elusive. Sometimes they travel under false names. Some slip in as refugees, using false passports and false histories. Others are returnees from Syria whose activities and encrypted Telegram communications slide beneath the radar, even as they are being watched. And overtaxed law enforcement agencies have made any number of mistakes, overlooking suspicious behavior or releasing suspects without adequate investigation – in part a consequence of political pressures and the fear of being accused of “Islamophobia” by politicians and the press.

As it turned out, the suspect in the Brussels knife attack was a former Belgian military officer already known to the police for his connections to fighters in Syria. To date, officials have not determined whether he has been to Syria or ISIS territory in Iraq.

But the contact with ISIS and other terror groups in the self-declared caliphate is a common link, not only among the known perpetrators of last November’s Paris attacks and the March attacks in Brussels, but among their alleged colleagues planning to attack Schiphol airport. Those two men, identified as the Tunisian Sofien Ayari and Syrian-Swedish Ossama Krayem, traveled by bus from Brussels to Amsterdam on Nov. 13, the day of the Paris massacre. Both used false IDs. They returned, still undetected, the following day.

Four months later, police raided a safe house used by the terror cell in Schaarbeek, a Brussels neighborhood, and retrieved a laptop computer containing files labeled “13 November.” Included in those files were documents referring not only to “Stade de France” and “Bataclan” – both targets in the Paris killings – but also to a “Schiphol group.”

“First They Came for Asia Bibi” by Douglas Murray

The same week that Mr Yousaf was extolling the idea that Britain is a proto-Nazi state and Pakistan a potential safe-haven, the Pakistani authorities saw the latest round of the interminable and unforgivable saga of Asia Bibi. This is the woman who has been on death-row in Pakistan for no crime other than the crime of being a Christian. Bibi has been awaiting execution for five years, purely because a neighbour claimed that Bibi had insulted Mohammed during an argument.

They attack the Conservative government of the UK for Nazism while not merely praising, but lauding as a safe haven, a state which actually persecutes and murders people because of their religion.

Which means that he is doing what many other people today are doing, which is knowingly to cover for a racist despotism, so long as it is despotism with an Islamic face.

Is Britain becoming a Nazi state? It would seem unlikely, but to listen to some of the critics of the Conservative government in recent days it would appear that we are only moments away from become a racist despotism.

Last week the convener of the Scottish Parliament’s Equalities and Human Rights Committee, one Christina McKelvie, pronounced that the Conservative party is displaying “some of the most right-wing reactionary politics that I’ve heard in my lifetime” and claimed that the Conservative party’s recent conference showed what will happen in Britain “if we become bystanders and do not speak out against discrimination.” She said that some recent Conservative proposals were “reminiscent of the rise of Nazism in the 1930s.”

Higher up the Scottish Nationalist Party food-chain, one of their MPs, Mhairi Black last week also compared the recent Conservative party conference to the Nazi party. She wrote without irony that she was vexed by its alleged “nationalism’, all the more “when that “nationalism” is used as a motivation or an excuse for racist, bigoted and small minded policy.” The policies of the Conservative party, she claimed, were increasingly “reminiscent of early 1930s Nazi Germany.” As though to demonstrate how sparse her knowledge of that period is, she concluded her piece by citing — as though no one could possibly have come across the quotation before — Pastor Martin Niemoller. “First they came for the Jews.”

Having sparked some criticism, other nationalists soon came to the aid of Ms Black. Notable among them was Humza Yousaf, one of the ministers of the SNP and himself a member of the Scottish Parliament. While many people on social media criticised Ms Black’s absurd rhetoric, he chose to back her up. “Those criticising, I have friends/family who have applied for dual nationality with Pakistan. Feel UK will be unbearable for Muslims in future.” This gained headlines of its own. But nobody pointed out the twin outrages of this grotesque nonsense.

How Islamic State Weaponized the Chat App to Direct Attacks on the West Police alarmed by emergence of militants that they say are using chat apps and social media to recruit militants in Europe from abroad By Stacy Meichtry and Sam Schechner

PARIS—A predawn attack on a French policeman’s home, the killing of a priest during Mass and a car bomb planted near Notre Dame Cathedral in recent months were plots that appeared isolated until investigators discovered a common thread.

Their authors had all allegedly been in contact with a man whom authorities identify as 29-year-old Rachid Kassim.

From somewhere in Islamic State-held territory in Iraq or Syria, authorities say, the French national had used the encrypted Telegram chat app and other social-media tools to contact people back home—mainly French teenagers who are believed to have little or no previous connection to the terror group or each other—and instruct them on how to mount attacks.

Investigators across Europe are alarmed by the rise of militants such as Mr. Kassim, who they suspect have developed a way to “remote control” attacks from far away. That is blurring the lines between assaults carried out by militants trained in Islamic State territory and those by so-called lone wolves who authorities assumed were acting without the direction or support of terror groups.

“What worries us is a new type of attacker who only appears to be acting alone,” said Hans-Georg Maassen, head of Germany’s domestic intelligence. “Such assailants are being steered virtually from abroad via instant messaging.”

Followers of Mr. Kassim’s private channel on Telegram received instructions in mid-August on how to buy cooking-gas canisters for a car bomb, according to a copy of the channel’s content provided to The Wall Street Journal by a person with access to it. The content was confirmed by French authorities.

Trial of Teenager ‘Safia S’ Starts Behind Closed Doors in Germany Case casts light on radicalization among teens and the challenge it presents for authorities By Ruth Bender

CELLE, Germany—The trial of a teenage girl accused of stabbing a policeman, in what officials allege was the first attack ordered by Islamic State on German soil, began on Thursday behind closed doors.

The case casts light on the growing phenomenon of radicalization among teens and the new challenge it presents for authorities, given the extensive legal protections juveniles enjoy in most Western countries.

This special status was on evidence on Thursday when the court in this small northern German town ordered reporters and the public out of the courtroom. The minor’s right to a closed-door trial, the judges argued, trumped even the “great public interest given the growing threat of Islamist terrorism.”

The 16-year-old, identified only as Safia S., is charged with attempted murder, aggravated assault and support of a foreign terrorist organization. Federal prosecutors say Islamic State operatives ordered her to commit an “act of martyrdom” and helped plan her knife attack on a policeman in Hannover in late February.

“We believe she was motivated and steered in her act by supporters of IS,” said Simon Henrichs, senior federal prosecutor, after the first day of the trial.

The defendant’s lawyer, Mutlu Günal, denied a terrorist motive, however. “That the attack happened is a fact and she apologized for it,” Mr. Günal said. “But there is no terrorist background.”

The accused faces a maximum sentence of 10 years in prison.

The case marks the first terror plot linked directly to the terror militia in Germany, a country that has seen a spate of attacks by Islamist extremist in recent months. Several of these followed a pattern observed around Europe of Islamic State operatives in the Middle East steering supporters remotely.